User:Burchard

I grew up in the Midwest and went to school in California, earning both my undergraduate and graduate degrees from Stanford University in Biology (1986) and Biochemistry (1993) respectively. After teaching briefly when my second child was small I joined Rosetta Inpharmatics, a biotechnology start-up in the Seattle area, as employee #11. Rosetta offered wide-open development opportunities to its small staff; our physicists and systems administrators trained me as a computational biologist, enabling me to develop probe design methods for our in-house microarray format later commercialized by Agilent. Merck & Co., Inc. acquired Rosetta in 2001, giving our teams opportunities to develop siRNA design methods, study functions of microRNAs, evaluate RNAi compounds and formulations, and perform meta-analysis of large 'omic data sets in support of basic and early discovery research. My recent interests include development of analytical methods for identification and validation of candidate therapeutic targets and target classes, characterization of epigenetic regulatory networks and investigation of non-coding RNA functions.